Regulation of Sertoli Cell and Germ Cell Differentation

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Tight junctions found between Sertoli cells are the major component of this barrier in the adult testis. Sertoli cell tight junctions are required for fertility and we know that their disruption leads to germ cell atresia and cessation of spermatogenesis. We have conclusively shown that FSH and androgen controls the blood-testis barrier, which involves the tight junctions between Sertoli cells. As the blood-testis barrier is essential for the production of viable sperm, we have focussed our efforts on determining if regulation of the tight junctions is similar in humans. Skip to content Search for: Search.

Sign up for our e-newsletter. The LIM homeobox gene Lhx9 is essential for mouse gonad formation. Nature : — Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol 6 : — Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat.

Regulation of Sertoli Cell Junctions | Hudson Institute of Medical Research

Biol Reprod 75 : 56 — A proposed role for VEGF isoforms in sex-specific vasculature development in the gonad. Reprod Domest Anim 43 : — Sex determination in mammalian germ cells: Extrinsic versus intrinsic factors. Reproduction : — Retinoid signaling determines germ cell fate in mice. Science : — FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell 19 : — One tissue, two fates: Molecular genetic events that underlie testis versus ovary development. Nat Rev Genet 5 : — Medline Web of Science Google Scholar.

Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. Genes Dev 17 : — Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes. Anat Histol Embryol 38 : — Mesonephric contribution to testis differentiation in the fetal mouse. Development : — Dev Dyn : — Spatially dynamic expression of Sry in mouse genital ridges. The genetic basis of XX—XY differences present before gonadal sex differentiation in the mouse.

Effect of bilateral denervation of the immature rat testis on testicular gonadotropin receptors and in vitro androgen production. Neuroendocrinology 57 : — The spatio-temporal pattern of testis organogenesis in mammals—insights from the mole. Int J Dev Biol 53 : — Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice.

Biol Reprod 86 : 1 — Leydig cells: From stem cells to aging. Mol Cell Endocrinol : 9 — Differential effects of superior and inferior spermatic nerves on testosterone secretion and spermatic blood flow in cats. Endocrinology : — The effects of testicular denervation on spermatogenesis in the Sprague-Dawley rat.

Neuroendocrinology 72 : 37 — The correlation of fine structure and function in steroid-secreting cells, with emphasis on those of the gonads. In The gonads ed. McKerns KW , — Appleton-Century-Crofts, New York. Google Scholar. Seminiferous cord formation is regulated by Hedgehog signaling in the marsupial. Biol Reprod 86 : Three-dimensional organization of testicular interstitial tissue and lymphatic space in the rat. Anat Rec : — CrossRef Medline Google Scholar. Desert hedgehog Dhh gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules.

Biol Reprod 63 : — Exocrine ontogenies: On the development of pancreatic acinar, ductual and centroacinar cells. Semin Cell Dev Biol 23 : — Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell : — Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.

Endothelial cell migration directs testis cord formation. Peritubular myoid cells are not the migrating population required for testis cord formation in the XY gonad. Sex Dev 2 : — Vascular—mesenchymal cross-talk through Vegf and Pdgf drives organ patterning.

Proc Natl Acad Sci : — Four-dimensional analysis of vascularization during primary development of an organ, the gonad. Expression and action of neurotropin-3 and nerve growth factor in embryonic and early postnatal rat testis development. Testis developmental phenotypes in neurotropin receptor trkA and trkC null mutations: Role in formation of seminiferous cords and germ cell survival.

Biol Reprod 66 : — Cushing H Cushing H. The employment of local anaesthesia in the radical cure of certain cases of hernia, with a note upon the nervous anatomy of the inguinal region. Ann Surg 31 : 1 — Intrinsic neuronal cell bodies in the rat ovary. Neurosci Lett : 65 — Intrinsic neurons in the rat ovary: An immunohistochemical study. Cell Tissue Res : 47 — Cellular architecture of the lamina propria of human seminiferous tubules. Origin and ontogeny of mammalian ovarian neurons.

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Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol : 14 — Testosterone levels influence mouse fetal Leydig cell progenitors through Notch signaling. Biol Reprod 88 : Opposing FGF and retinoid pathways control ventral pattern, neuronal differentiation, and segmentation during body axis extension. Neuron 40 : 65 — Migratory and postmigratory mouse primordial germ cells behave differently in culture.

Cell 44 : — Dym M Dym M. Basement membrane regulation of Sertoli cells. Endocr Rev 15 : — Mammalian sex determination—insights from humans and mice. Chromosome Res 20 : — Somatic and germ cell interactions during histogenetic aggregation of mouse fetal testes. Exp Cell Res : — Lymph vasculature system of the interstitial tissue of the testis as revealed by electron microscopy. J Reprod Fertil 19 : — Comparative observations on intertubular lymphatics and the organization of the interstitial tissue of the mammalian testis.

Biol Reprod 9 : — Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Testicular innervation is necessary for the response of plasma testosterone levels to acute stress. Biol Reprod : — Neuronal elements in the testis of the rhesus monkey: Ontogeny, characterization and relationship to testicular cells. Neuroendocrinology 71 : 43 — Homeoproteins six1 and six4 regulate male sex determination and mouse gonadal development.

Testosterone Retention Mechanism in Sertoli cells: A Biochemical Perspective

Dev Cell 26 : — Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice. Biol Reprod 87 : Ultrastructure of testicular macrophages in aging mice. J Morphol : 39 — Deprival of testicular innervation induces apoptosis of Leydig cells via caspasedependent signaling: A novel survival pathway revealed.

Regulation of Sertoli Cell and Germ Cell Differentiation

Biochem Biophys Res Commun : — Fetal Leydig cell origin and development. Initiating meiosis: The case for retinoic acid. Normal structure and expression of Zfy genes in XY female mice mutant in Tdy. Extracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro. J Cell Biol : — Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis.

Early gonadogenesis in mammals: Significance of long and narrow gonadal structures. The comparative anatomy of the blood-supply of the mammalian testis. Proc Zool Soc Lond : — Vascular patterns of the mammalian testis and their functional significance. J Exp Biol 26 : — Germ cell deficiency causes testis cord differentiation in reconstituted mouse fetal ovaries. J Exp Zool : 61 — Neonatal mouse gonocyte proliferation assayed by an in vitro clonogenic method. J Reprod Fertil : — Genes Cells 1 : — Lymph vessel density in seminomatous testicular cancer assessed with the specific lymphatic endothelium cell markers D and LYVE Correlation with pathologic parameters and clinical outcome.

Urol Oncol 31 : — The origin of lymphatic capillaries in murine testes. J Androl 33 : — A critical time window of Sry action in gonadal sex determination in mice. FGF signaling directs a center-to-pole expansion of tubulogenesis in mouse testis differentiation. Myofibroblasts in the lamina propria of human seminiferous tubules are dynamic structures of heterogenous phenotype. Arch Histol Cytol 59 : — Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.

Mol Reprod Dev 77 : — Am J Med Genet 87 : — Huhtaniemi I Huhtaniemi I. Endocrine function and regulation of the fetal and neonatal testis. Int J Dev Biol 33 : — Changes in the concentration and size of testicular macrophages during development. Biol Reprod 43 : — Development of cytoplasmic digitations between Leydig cells and testicular macrophages of the rat. Physiological interactions between macrophages and Leydig cells. Exp Biol Med Maywood : 1 — 7. Abnormalities of testicular descent.

Testis development requires the repression of Wnt4 by Fgf9 signaling. Dev Biol : 24 — Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.

PLoS Genet 8 : e Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Jost A Jost A. Recherches sur la differenciation sexuelle de l'embryon de lapin. Arch Anat Microsc Morphol Exp 36 : — Problems of fetal endocrinology: The gonadal and hypophyseal hormones. Recent Prog Horm Res 8 : — Web of Science Google Scholar. Sertoli cells of the mouse testis originate from the coelomic epithelium.

Male-to-female sex reversal in M33 mutant mice. Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Stimulation of interstitial cell growth after selective destruction of foetal Leydig cells in the testis of postnatal rats. Cell Tissue Res : 89 — Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.

PLoS Biol 4 : e Fibroblast growth factor receptor 2 regulates proliferation and Sertoli cell differentiation during male sex determination. Molecular and genetic regulation of testis descent and external genitalia development. Dev Biol : 1 — Male development of chromosomally female mice transgenic for Sry. Retinoic acid regulates sex-specific timing of meiotic initiation in mice.

WT-1 is required for early kidney development.

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Regulation of Sertoli cell and germ cell differentation.

Cell 74 : — PLoS Biol 6 : e Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet 7 : e Rapid estrogen signalling in mouse primordial germ cells. Testicular differentiation occurs in absence of Rspondin-1 and Sox9 in mouse sex reversals. Clonal analysis of the origin of primordial germ cells in the mouse. Ciba Found Symp : 68 — Anatomical and functional evidence for a neural hypothalamic—testicular pathway that is independent of the pituitary. Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern.

Role of neurotropins in rat embryonic testis morphogenesis cord formation.

Biol Reprod 62 : — Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: Identification of signaling mechanisms involved. Organotypic culture, a powerful model for studying rat and mouse fetal testis development. Comparative ultrastructural and histochemical studies of the interstitial cells of the rat testis during fetal and postnatal development.

J Reprod Fertil 29 : — Specificity of a new lipid mediator produced by testicular and peritoneal macrophages on steroidogenesis. Int J Androl 23 : — Production of hydroxycholesterol by testicular macrophages and its effects on Leydig cells. Biol Reprod 64 : — A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77 : — Cloning of a novel retinoic-acid metabolizing cytochrome P, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development.

Mech Dev : — Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Maden M Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci 8 : — Peritubular myoid cells in the testis: Their structure and function. Arch Histol Cytol 59 : 1 — EMBO J 24 : — DMRT1 prevents female reprogramming in the postnatal mammalian testis.

The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Hum Reprod Update 5 : — Testis of prepubertal rhesus monkeys receives a dual catecholaminergic input provided by the extrinsic innervation and an intragonadal source of catecholamines. Biol Reprod 55 : — J Androl 17 : — Evidence for catecholaminergic, neuronlike cells in the adult human testis: Changes associated with testicular pathologies.

J Androl 20 : — In vitro sex differentiation of congeneic germinal cell aplastic gonads. Am J Obstet Gynecol : 83 — Quantification of sex chromosomal influence s on the somatic growth of fetal gonads in vivo. Am J Obstet Gynecol : — Dax1 regulates testis cord organization during gonadal differentiation. Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis.

Biol Reprod 84 : — Merchant H Merchant H. Rat gonadal and ovarian organogenesis with and without germ cells. An ultrastructural study. Dev Biol 44 : 1 — The role of the mesonephros in cell differentiation and morphogenesis of the mouse fetal testis. Int J Dev Biol 37 : — Neuroendocrine marker substance in human Leydig cells—changes by disturbance of testicular function.

Andrologia 25 : — The tunica albuginea of the human testis is characterized by complex contraction and relaxation activities regulated by cyclic GMP. J Clin Endocrinol Metab 87 : — Structure, cytochemistry, endocytic activity, and immunoglobulin Fc receptors of rat testicular interstitial-tissue macrophages. Mittwoch U Mittwoch U. Phenotypic manifestations during the development of the dominant and default gonads in mammals and birds. J Exp Zool : — Growth of differentiating testes and ovaries. Defects of urogenital development in mice lacking Emx2.

Human primordial germ cells migrate along nerve fibers and Schwann cells from the dorsal hind gut mesentery to the gonadal ridge. Mol Hum Reprod 16 : — Time-lapse analysis of living mouse germ cell migration. Some experimental observations relating to visceral pain. Surgery 3 : — Dev Biol : 74 — Effects of denervation and local 6-hydroxydopamine injection on testicular growth in rats. Experientia 38 : — Testis determination requires insulin receptor family function in mice.

Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse. Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis. Macrophages in the interstitial tissue of the rat testis. The technique of testicular biopsy with a note on testicular pain.

Proliferation of Sertoli cells in fetal and postnatal rats: A quantitative autoradiographic study. Endocrinology of the mammalian fetal testis. Reproduction : 37 — Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. J Cell Sci : — A cellular study of human testis development.

Sex Dev 1 : — Loss of Wnt4a and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum Mol Genet 16 : — Otulakowski B Otulakowski B. Innervation of the testis in human fetuses from 16th to 22nd week. Folia Morphol Warsz 51 : 81 — In situ analysis of fetal prepubertal and adult XX—XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY. Distinct roles for steroidogenic factor 1 and desert hedgehog pathways in fetal and adult Leydig cell development.

Sex chimaerism, fertility and sex determination in the mouse. Germ-cell deficient gcd , an insertional mutation manifested as infertility in transgenic mice. Proc Natl Acad Sci 88 : — Ultrastructure of gonadal ridge in male and female pig embryos. Anat Embryol Berl : 20 — Dual role of immune cells in the testis: Protective or pathogenic for germ cells? Spermatogenesis 3 : e Functional afferent innervation of testis.

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J Neurophysiol 36 : — A developmental study of the Desert hedgehog-null mouse testis. Biol Reprod 65 : — Sry and the hesitant beginnings of male development. Dev Biol : 13 — Sox10 gain-of-function causes XX sex reversal in mice: Implications for human 22q-linked disorders of sex development. Hum Mol Genet 19 : — The molecular genetics of sex determination and sex reversal in mammals. Semin Reprod Med 30 : — Mechanisms guiding primordial germ cell migration: Strategies from different organisms. Nat Rev Mol Cell Biol 11 : 37 — Testicular signaling: Incoming and outgoing messages.

Ann N Y Acad Sci : — On cell contribution to gonadal soma formation in quail-chick chimeras during the indifferent stage of gonadal development. Anat Embryol Berl : — The development of the interstitial cells in the testis of the albino rat. Acta Anat Basel 37 : — Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptor in mice suggests functional roles in testicular and epididymal morphogenesis.

Biol Reprod 61 : — Sry induces cell proliferation in the mouse gonad. Development : 65 — Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds. Endocr Rev 30 : — Anatomy, vasculature, innervation and fluids of the male reproductive tract. In The physiology of reproduction ed. Knobil E, Neill JD , pp. Raven Press, New York. Testicular dysgenesis syndrome: Mechanistic insights and potential new downstream effects. Fertil Steril 89 : e33 — e A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.

Structural characterization of proteoglycans produced by testicular peritubular cells and Sertoli cells. J Biol Chem : — Cooperativity between Sertoli cells and testicular peritubular cells in the production and deposition of extracellular matrix components. Identity of M2A D antigen and gp36 Aggrus, T1A-2 , podoplanin in human developing testis, testicular carcinoma in situ and germ-cell tumours. Virchows Arch : — Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.

Origin, development and regulation of human Leydig cells. Horm Res Paediatr 73 : 93 — Three-dimensional imaging of Prox1-EGFP transgenic mouse gonads reveals divergent modes of lymphangiogenesis in the testis and ovary. Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Notch signaling maintains Leydig progenitor cells in the mouse testis.

Biol Reprod 68 : — Cooperativity between Sertoli cells and peritubular myoid cells in the formation of the basal lamina in the seminiferous tubule. Tips, stalks, tubes: Notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis. Cold Spring Harb Perspect Med 2 : a Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.

Proliferation activity of gonocytes, Sertoli cells and interstitial cells during testicular development in mice. J Reprod Fertil 93 : — Sox9 induces testis development in XX transgenic mice. Nat Genet 28 : — Mammalian sex determination: From gonads to brain. Mol Genet Metab 65 : 74 — Cell 79 : — The game plan: Cellular and molecular mechanisms of mammalian testis development. Curr Top Dev Biol 90C : — The molecular and cellular basis of gonadal sex reversal in mice and humans. Wiley Interdiscip Rev Dev Biol 1 : — Development of the human fetal testis.

Pediatr Pathol Lab Med 16 : 9 — Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. Sex determination and gonadal development in mammals.

Physiol Rev 87 : 1 — Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Testicular dysgenesis syndrome: Foetal origin of adult reproductive problems. Clin Endocrinol Oxf 71 : — The testis and referred pain. Brain 56 : — Genes Dev 16 : — Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse. Requirement of Bmp8b for the generation of primordial germ cells in the mouse. Mol Endocrinol 14 : —