Medicated Intrauterine Devices: Physiological and Clinical Aspects

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Acta Obstet.

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Hafez, E. Mode of action of inert, copper and steroid-releasing IUDs. Hagenfeldt, K. Biochemical and morphological changes in the human endometrium induced by the Progestasert device. Hasson, H.

BIO-XII-04-05,IUDs, Oral and Surgical Methods of contra ception, Pradeep Kshetrapal channel

Copper IUDs. Herr, J. Decidual cells in the human ovary at term. Incidence, gross anatomy and ultra- structural features of merocrine secretion. Smooth muscle within ovarian decidual nodules: a link to leiomyomatosis peritonealis disseminata? Lawn, A. The ultrastructure of human decidual and predecidual cells. Liebig, W. Decidualisation of the endometrial stromal cell. Ludwig, K.

Acta Anat , 99 , Google Scholar. Mackles, A. Cellular atypia in endometrial glands Arias-Stella reaction as an aid in the diagnosis of ectopic pregnancy. Gynecol , 81 , —19 Google Scholar. Martinez-Manautou, J. Contraception by Intrauterine release of progesterone.

Clinical results. Endometrial morphology in woman exposed to uterine systems releasing progesterone. Moyer, D. Reactions of human endometrium to the Intrauterine foreign body. Long-term effects on the endometrial histology and cytology. Noyes, R. Dating the endometrial biopsy. Pharriss, B. Progestasert: a uterine therapeutic system for long-term contraception. Philosophy and clinical efficacy. Pildes, R. Atypical cellular changes in endometrial glands associated with ectopic pregnancy.

Piotrow, P. IUDs-update on safety, effectiveness and research. Rosado, A. Intrauterine contraception with Progesterone-T device—interference with metabolic-activity and capacitation of spermatozoa. Contraception , 9 , 39—51 CrossRef Google Scholar. Schwarz, W. Scommegna, A. Fertility control by Intrauterine release of progesterone. Spornitz, U. Ultrastructure of decidual response to Progestasert IUD.

The effect of the progesterone releasing IUD on the morphology of the endometrium and the oviduct.

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Sutcliffe, R. The protein composition of the fibrinoid material at the human uteroplacental interface. Tatum, H. Intrauterine contraception. Clinical aspects of Intrauterine contraception. Circumspection Very few, if any, sperm reach the ovum in the fallopian tube. The progestin-releasing IUD adds the endometrial action of the progestin to the foreign body reaction. The endometrium becomes decidualized with atrophy of the glands.

Mechanism of action Copper-releasing IUCs When used as a regular or emergency method of contraception, copper-releasing IUCs act primarily to prevent fertilization. Emergency contraceptive pills To make an informed choice, women must know that ECPs—like the birth control pill, patch, ring, shot, and implant, 76 and even like breastfeeding 77 —prevent pregnancy primarily by delaying or inhibiting ovulation and inhibiting fertilization, but may at times inhibit implantation of a fertilized egg in the endometrium. However, women should also be informed that the best available evidence indicates that ECPs prevent pregnancy by mechanisms that do not involve interference with post-fertilization events.

ECPs do not cause abortion 78 or harm an established pregnancy. One study has demonstrated that UP can delay ovulation. Another study found that UPA altered the endometrium, but whether this change would inhibit implantation is unknown. Early treatment with ECPs containing only the progestin levonorgestrel has been show to impair the ovulatory process and luteal function.


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Several clinical studies have shown that combined ECPs containing ethinyl estradiol and levonorgestrel can inhibit or delay ovulation. How does EC work? In , a judicial review ruled that pregnancy begins at implantation, not fertilisation. Copper-bearing intrauterine device Cu-IUD. Copper is toxic to the ovum and sperm and thus the copper-bearing intrauterine device Cu-IUD is effective immediately after insertion and works primarily by inhibiting fertilisation.

The precise mode of action of levonorgestrel LNG is incompletely understood but it is thought to work primarily by inhibition of ovulation.


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From Wikipedia, the free encyclopedia. For Intrauterine death, see stillbirth. Form of birth control involving a device placed in the uterus. Main article: Copper IUDs. Main article: Hormonal IUDs. Blueprints Obstetrics and Gynecology. Contraception guide. NHS Choices. Retrieved 2 March New England Journal of Medicine. Retrieved Obstetrics and Gynecology. Clinical reproductive medicine and surgery. Philadelphia: Mosby. Joseph eds. The Johns Hopkins manual of gynecology and obstetrics 4th ed.

January Retrieved 14 March Hatcher, R.


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    June 12, Retrieved July 14, Copper ions released from the IUD create an environment that is toxic to sperm, preventing fertilization. Archived from the original on September 28, Retrieved April 27, December Human Reproduction Update. Int J Gynaecol Obstet. A clinical guide for contraception 5th ed.

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    Contraceptive technology 20th rev. Although the precise mechanism of action is not known, currently available IUCs work primarily by preventing sperm from fertilizing ova. Exposure to a foreign body causes a sterile inflammatory reaction in the intrauterine environment that is toxic to sperm and ova and impairs implantation. Journal of Mid-Life Health. November The Medical Letter on Drugs and Therapies. July 6, Retrieved Oct 6, Mayo Clinic. Retrieved 30 November Feminine Wear. Retrieved 22 December Retrieved 21 November Mishell Humana Press. Danforth's Obstetrics and Gynecology.

    Retrieved 25 March Pamela; Jamieson, Denise J. Medical Eligibility Criteria for Contraceptive Use, ". Recommendations and Reports. August Gabbe; et al. Archived from the original on In Hatcher, Robert A. Contraceptive technology 20th revised ed. New York: Ardent Media.

    PRIME PubMed | Intrauterine copper contraceptive devices and allergy to copper and nicke

    Clinical guidance: emergency contraception PDF. London: Royal College of Obstetricians and Gynaecologists. Archived from the original PDF on August 20, March Archived from the original PDF on 20 August Retrieved 24 March Princeton University Press. The New York Times. Retrieved 8 January July 14, Radio Free Asia. January 13, Birth control methods G02B , G03A. Fertility awareness Billings ovulation method Creighton Model , etc. Contraceptive patch Extended cycle Injectable Combined vaginal ring Pill. Ormeloxifene Centchroman. Emergency contraception Ulipristal acetate Yuzpe regimen Levonorgestrel.

    Copper Hormone. Female : Essure Tubal ligation Male : Vasectomy. Reversible inhibition of sperm under guidance Vasalgel.