Handbook of Drug-nutrient Interactions

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From the time a fetus is viable through adolescence, the body is undergoing exponential growth and development. However, the development of organ function and body composition does not occur in a linear fashion. How the body processes nutrients and medications from birth through age 2 changes rapidly. There is also a significant change as the body begins the growth spurt through adolescence. Electrolyte abnormalities, glucose intolerance, and protein malnutrition are common in the pediatric intensive care unit PICU patient.

There is a delicate balance between maintaining nutritional and therapeutic goals in the PICU setting, but these should never be considered mutually exclusive.

Drug interactions Medicine and nutrition

Various classifications of drug—nutrient interactions have been proposed, but one useful classification that is based on the drug's course through the body is as follows 4 :. Ex-vivo bioinactivation refers to the interaction between the drug and the nutritional formulation through biochemical or physical reactions. A classic example of this form of interaction is the creation of a precipitate in an enteral feeding tube by a drug that has been administered before all the enteral formula has been flushed through.

This form of interaction occurs when the drug and the nutrient are in physical contact, and usually occurs in the feeding tube or the central venous catheter. Interactions affecting absorption affect drugs and nutrients delivered orally or enterally.

Handbook of drug-nutrient interactions

These interactions have the potential to cause either an increase or decrease in the bioavailability of the drug. A variety of medications, including carbamazepine, quinolones, phenytoin, and warfarin, have significantly impaired absorption in the presence of enteral formulas. Interactions affecting systemic disposition occur after the drug and the nutrient have entered the systemic circulation. In this case, the classic example is grapefruit juice causing inhibition of the cytochrome P 3A4 system and increasing the bioavailability of drugs like cyclosporine.

The final type of drug—nutrient interaction affects the elimination of drugs or nutrients, which may involve the modulation of renal or enterohepatic elimination. This chapter will focus on the most common conditions and medications and potential nutrient interactions.

Vitamin-B12 status of patients on long-term metformin therapy. Br Med J ;19 2 Understanding drug-nutrient interactions and their clinical relevance.

WIC Information for Providers

Pharmaceutical Solutions Monograph Mason et al. Symposium 8: Drugs and nutrition Important drug-nutrient interactions.

Handbook of Drug-nutrient Interactions - Google книги

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Diabetologia ;13 3 A Growing Public Health Concern Significant increases in global medication utilization have resulted in myriad unintended consequences, among which is a dramatic rise in drug-nutrient interactions DNIs. Handbook of drug-nutrient interactions. Humana Press Raats et al. Food for the ageing population. Woodhead Publishing Limited Effects of vitamin C deficiency on action of different types of barbi- turates. Effects of isoniazid on pyridoxine metabolism.

Effect of isoniazid on vitamin B6 metabolism; its possible significance in producing isoniazid neuritis.

McLean AEM. Drug nutrient interactions from experiment to epidemiology. Alan R. Liss, New York, NY, , pp. Krishnaswamy K.

Recensie(s)

Drug metabolism and pharmacokinetics in malnutrition. Pharmacokinetics of drugs in obesity. Hermus RJJ. A discussion of drug effects on nutrient absorption, transport and metabolism. Prediction of the cause, effects, and prevention of drug-nutrient interactions using attributes and attribute values.

(E book) Handbook of Drug Nutrient Interactions J. Boullata, V. Armenti (Humana, 2004)

Process guides on drug and nutrient interactions in arthritics. Process guides on drug-nutrient interactions for health care providers and patients. Drug interference with the assessment of nutritional status. Drug effects on nutrient absorption, transport, and metabolism. Chan L-N. Drug-nutrient interaction in clinical nutrition. Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Cheymol G. Effects of obesity on pharmacokinetics: implications for drug therapy.

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